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FIVE 2019 MOST COLUMBUS AND EINSTEIN GRANTS BRING NT90 MILLION TO TMU

Announcement
Poster:Post date:2020-02-14
 Assistant Professors Cheng-Yi Chen, Tsung-Ling Lee, Wei-Chen Huang, Yu-Cheng Hsiao and Tsai-Tsen Liao received 2019 MOST Einstein and Columbus funding totaling NT90 million.




Assistant Professor Tsai-Tsen Liao, College of Medicine

Assistant Professor Tsai-Tsen Liao researches tumor biology, epigenetics and cancer molecular biology. Recently she has been working on anti-tumor mechanisms, searching for novel genes as potential treatment targets. Her research found that ARID3B, a member of the AT-rich interacting domain protein family, can form a complex that affects chromatin structure, which can induce cancer stemness in head and neck cancer. This is the first research indicating ARID3B’s ability to regulate chromatin structure and activate stem cell genes.
 
The Ministry of Science and Technology’s Einstein Program is funding this research into epigenetic regulatory mechanisms for colorectal cancer stem cells to determine the mechanism of stemness. Colorectal cancer is Taiwan’s third most deadly cancer, and surgery, chemotherapy and radiation therapy often fail to stop metastasis and recurrence. Cancer stemness important due to its links to resistance to treatment, metastasis and recurrence as the cancer exacerbates. As treatment strategies locking onto and eliminating colorectal cancer stem cells tend to fail, leading to a stem cell niche where new cancer stem cells form, Dr. Liao’s research instead aims to block cancer stem cell development.
Last modification time:2020-03-03 AM 11:46

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